Is Mesotherapy and Microneedling the Same Thing

Mesotherapy and microneedling are two popular cosmetic procedures often sought after for their skin rejuvenating benefits. While both treatments involve the use of needles, they serve different purposes and utilize distinct techniques. In this blog we will explain the most important concern that everyone has in there minds Is Mesotherapy and Microneedling the Same Thing?

What is Mesotherapy?

Definition and Origins

Mesotherapy is a cosmetic procedure that involves the injection of small amounts of pharmaceuticals, vitamins, minerals, and other active ingredients directly into the mesoderm, which is the middle layer of the skin. This technique was first developed by Dr. Michel Pistor in the 1950s in France and has since gained popularity worldwide for its ability to address various skin concerns.

Mesotherapy derives its name from the term “mesoderm,” which refers to the middle layer of the skin where the injections are administered. The concept behind mesotherapy is based on the principle of delivering therapeutic agents directly to the target area, bypassing the digestive system and bloodstream, to achieve faster and more effective results. Dr. Michel Pistor pioneered this technique as a minimally invasive alternative to traditional medical treatments for conditions such as pain management and vascular disorders.

Procedure and Mechanism

During a mesotherapy session, a series of micro-injections are administered using a fine needle or mesotherapy gun. The specific combination of ingredients injected depends on the individual’s unique needs and the intended outcome of the treatment. These ingredients may include vitamins, minerals, amino acids, hyaluronic acid, and other substances known for their skin-rejuvenating properties. The injections are typically administered at shallow depths into the mesoderm, where they can directly target the desired area and stimulate cellular activity.

The mechanism of action behind mesotherapy involves multiple factors. The injected ingredients work synergistically to improve circulation, promote collagen and elastin production, hydrate the skin, and reduce inflammation. By delivering nutrients and active compounds directly to the skin’s deeper layers, mesotherapy can effectively address a wide range of concerns, including wrinkles, fine lines, acne scars, hyperpigmentation, and cellulite.

Target Areas and Benefits

Mesotherapy can be used to treat various areas of the body, including the face, neck, décolletage, hands, scalp, and body. Some common benefits of mesotherapy include:

  • Improved skin texture and tone
  • Reduction of wrinkles and fine lines
  • Tightening and firming of sagging skin
  • Lightening of hyperpigmentation and dark spots
  • Smoothing of acne scars and other skin imperfections
  • Reduction of cellulite and localized fat deposits
  • Stimulation of hair growth and prevention of hair loss

What is Microneedling?

Definition and History

Microneedling, also known as collagen induction therapy, is a minimally invasive cosmetic procedure that involves the use of a device equipped with fine needles to create controlled micro-injuries to the skin. These micro-injuries stimulate the body’s natural healing process, promoting the production of collagen and elastin, which are essential proteins for maintaining skin elasticity and firmness.

The history of microneedling dates back to ancient times when various cultures used similar techniques to improve skin texture and treat scars. However, modern microneedling as we know it today has evolved significantly, thanks to advancements in technology and medical research.

Techniques and Devices

Microneedling techniques can vary depending on the specific device used and the desired outcome. The most common technique involves using a handheld device with multiple fine needles that are gently rolled or stamped across the skin. These needles create tiny punctures in the skin, triggering the body’s natural wound healing response.

There are also more advanced microneedling devices that utilize automated technology to precisely control the depth and speed of needle penetration. Additionally, some devices may incorporate additional features such as radiofrequency or LED light therapy to enhance results.

Benefits and Applications

Microneedling offers a wide range of benefits for the skin, making it a popular choice for addressing various dermatological concerns. Some of the key benefits of microneedling include:

  • Improved Skin Texture: Microneedling stimulates collagen and elastin production, leading to smoother, more youthful-looking skin.
  • Reduced Scarring: Microneedling can help reduce the appearance of acne scars, surgical scars, and stretch marks by promoting collagen remodeling and skin regeneration.
  • Tightened Pores: The micro-injuries created during microneedling can help tighten enlarged pores, resulting in a more refined skin texture.
  • Enhanced Product Absorption: The microchannels created by microneedling allow for better absorption of skincare products, maximizing their effectiveness.
  • Reduced Fine Lines and Wrinkles: Microneedling can help diminish the appearance of fine lines and wrinkles by stimulating collagen production and promoting skin tightening.

Is Mesotherapy and Microneedling the Same Thing? Key Differences

Key Differences of Mesotherapy and Microneedling

Treatment Objectives

Mesotherapy primarily aims to deliver specific nutrients, vitamins, and medications directly into the mesoderm of the skin. The objective is to nourish the skin, promote collagen production, improve circulation, and address various cosmetic concerns such as wrinkles, fine lines, and skin laxity.

On the other hand, microneedling focuses on inducing controlled micro-injuries to the skin, stimulating the body’s natural healing response. The main objective of microneedling is to trigger collagen and elastin production, resulting in firmer, smoother skin texture and overall rejuvenation.

Depth of Penetration

In mesotherapy, the depth of penetration is relatively shallow, typically reaching the mesoderm, which is the middle layer of the skin. The injections are administered using fine needles, penetrating only a few millimeters into the skin. In contrast, microneedling involves the use of a device equipped with tiny needles that penetrate the skin to varying depths, depending on the specific technique and device used. The depth of penetration in microneedling can range from superficial (0.5 mm) to deeper levels (up to 2.5 mm), targeting different skin layers and structures.

Substances Used

Mesotherapy involves the injection of a customized cocktail of vitamins, minerals, amino acids, hyaluronic acid, and other pharmaceutical agents tailored to the individual’s specific skin concerns. These substances are directly infused into the skin to address issues such as hydration, firmness, and pigmentation.

In contrast, microneedling does not typically involve the use of additional substances during the procedure. Instead, the focus is on creating micro-injuries to stimulate the body’s natural collagen and elastin production without the need for external additives.

Specific Conditions Treated

Mesotherapy is versatile and can be used to address a wide range of cosmetic concerns, including aging skin, wrinkles, fine lines, acne scars, hyperpigmentation, cellulite, and hair loss. It is also commonly used for facial rejuvenation and body contouring purposes. Microneedling is primarily employed for skin rejuvenation and improvement of texture and tone.

It is effective in treating acne scars, enlarged pores, stretch marks, uneven skin tone, and mild to moderate signs of aging. microneedling can be used in combination with other treatments to enhance their efficacy, such as the application of topical serums or platelet-rich plasma (PRP) therapy.

Similarities Between Mesotherapy and Microneedling

Mesotherapy and microneedling, despite being distinct procedures, share several similarities in their approach to skin rejuvenation and collagen induction.

Collagen Induction

Both mesotherapy and microneedling aim to stimulate collagen production in the skin. Collagen is a protein responsible for the skin’s strength and elasticity. By inducing controlled micro-injuries, microneedling triggers the body’s natural healing process, leading to increased collagen synthesis. Similarly, mesotherapy delivers active ingredients directly into the skin, promoting collagen production and improving skin firmness and texture over time.

Skin Rejuvenation

One of the primary objectives of both mesotherapy and microneedling is skin rejuvenation. These treatments can address various skin concerns, including fine lines, wrinkles, acne scars, and uneven texture. By promoting collagen and elastin production, mesotherapy and microneedling help to restore a more youthful appearance and improve overall skin health. Additionally, both procedures can enhance the effectiveness of skincare products by improving their absorption into the skin.

Minimally Invasive Procedures

Another similarity between mesotherapy and microneedling is that they are minimally invasive procedures. Unlike surgical interventions, such as facelifts or laser resurfacing, mesotherapy and microneedling are non-surgical treatments that require little to no downtime. Patients can typically resume their daily activities immediately following the procedure, with minimal discomfort and side effects. both treatments offer gradual, natural-looking results, making them popular options for individuals seeking subtle improvements in their skin’s appearance.

Effectiveness and Results

Mesotherapy and microneedling are both renowned for their effectiveness in rejuvenating the skin and addressing various dermatological concerns. Understanding the expected outcomes of each procedure, as well as their long-term effects, is crucial for individuals considering these treatments.

Expected Outcomes of Mesotherapy

Mesotherapy is valued for its ability to deliver nutrients directly to the skin, promoting collagen production, improving circulation, and reducing inflammation. As a result, patients often experience smoother, firmer skin with diminished fine lines, wrinkles, and uneven texture. Mesotherapy can also target specific concerns such as acne, hyperpigmentation, and hair loss, providing customized solutions for individual needs.

Long-term Effects of Microneedling

Microneedling stimulates the body’s natural healing response, triggering collagen and elastin production to improve skin texture, tone, and elasticity. Over time, the cumulative effects of microneedling can lead to significant improvements in the appearance of scars, stretch marks, and age-related skin laxity. microneedling can enhance the absorption of topical skincare products, maximizing their efficacy for long-lasting results.

Skin Rejuvenation

Choosing the Right Procedure

When considering cosmetic procedures such as mesotherapy or microneedling, it’s crucial to make an informed decision based on your specific needs and goals. Here are some key factors to consider when choosing the right procedure for you:

Factors to Consider

  • Skin Concerns: Identify your primary skin concerns, whether it’s aging signs like wrinkles and fine lines, acne scars, uneven skin tone, or other dermatological issues. Different procedures may target specific concerns more effectively.
  • Treatment Objectives: Clarify your treatment goals—are you seeking overall skin rejuvenation, targeted improvement in specific areas, or a combination of both? Understanding your objectives will help you select the most appropriate procedure.
  • Skin Type: Consider your skin type and sensitivity. Certain treatments may be better suited for particular skin types, and your dermatologist or aesthetician can recommend the most suitable option based on your skin’s characteristics.
  • Downtime: Assess your availability for downtime and recovery. While some procedures require minimal downtime with little to no disruption to daily activities, others may involve more significant downtime and post-treatment care.
  • Budget: Determine your budget for cosmetic treatments and inquire about the cost of each procedure. Remember to consider not only the upfront cost but also any potential long-term maintenance expenses.
  • Medical History: Discuss your medical history with your healthcare provider to ensure that the chosen procedure is safe for you. Certain medical conditions or medications may impact your eligibility for specific treatments.
  • Expectations: Manage your expectations realistically. While cosmetic procedures can yield noticeable improvements in skin appearance, they may not always deliver perfection or immediate results. Understanding the expected outcomes can help prevent disappointment.

Consultation with a Dermatologist or Aesthetician

Once you’ve considered these factors, schedule a consultation with a qualified dermatologist or aesthetician to further discuss your options and receive personalized recommendations. During the consultation:

  • Assessment: Your provider will evaluate your skin condition, discuss your concerns and goals, and recommend the most suitable treatment plan based on your individual needs.
  • Education: Gain a comprehensive understanding of the chosen procedure, including its mechanism of action, expected results, potential risks, and any pre- and post-treatment instructions.
  • Customization: Your treatment plan will be tailored to address your specific concerns and preferences, ensuring optimal outcomes and patient satisfaction.
  • Q&A: Take this opportunity to ask any questions or express any concerns you may have about the procedure. Your provider will address your queries and alleviate any apprehensions you may have.


while mesotherapy and microneedling offer distinct benefits and applications, they both serve as effective treatments for skin rejuvenation and improvement. Mesotherapy involves the injection of nutrients and medications directly into the skin’s middle layer, promoting collagen production and addressing specific concerns. On the other hand, microneedling induces controlled micro-injuries to stimulate the body’s natural healing process, resulting in firmer, smoother skin texture.


Is mesotherapy painful?

Mesotherapy is generally well-tolerated by most patients. While some individuals may experience mild discomfort during the procedure, topical anesthesia can be applied to minimize any discomfort.

How many sessions of microneedling are needed to see results?

The number of microneedling sessions required depends on individual skin concerns and goals. Typically, a series of 3-6 treatments spaced 4-6 weeks apart is recommended for optimal results.

Can mesotherapy and microneedling be combined in a single session?

Yes, mesotherapy and microneedling can be combined to enhance the benefits of both treatments. This approach allows for deeper product penetration and maximizes collagen stimulation, resulting in more comprehensive results.

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